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Successful Xenograft of Endoscopic Ultrasound-Guided Fine-Needle Aspiration Specimen from Human Extrahepatic Cholangiocarcinoma into an Immunodeficient Mouse.

作者信息

Jang Se Young, Bae Han Ik, Lee In Kyu, Park Hwan Ki, Cho Chang-Min

机构信息

Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Korea.

Department of Pathology, Kyungpook National University School of Medicine, Daegu, Korea.

出版信息

Gut Liver. 2015 Nov 23;9(6):805-8. doi: 10.5009/gnl14279.

DOI:10.5009/gnl14279
PMID:26087785
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4625712/
Abstract

Patient-derived tumor xenograft is the transfer of primary human tumors directly into an immunodeficient mouse. Patient-derived tumor xenograft plays an important role in the development and evaluation of new chemotherapeutic agents. We succeeded in generating a patient-derived tumor xenograft of a biliary tumor obtained by endoscopic ultrasound-guided fine-needle aspiration from a patient who had an inoperable extrahepatic cholangiocarcinoma. This patient-derived tumor xenograft will be a promising tool for individualized cancer therapy and can be used in developing new chemotherapeutic agents for the treatment of biliary cancer in the future.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c966/4625712/7de4a31177c2/gnl-09-805f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c966/4625712/886e3416dd99/gnl-09-805f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c966/4625712/e8934df2d7c5/gnl-09-805f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c966/4625712/7de4a31177c2/gnl-09-805f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c966/4625712/886e3416dd99/gnl-09-805f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c966/4625712/e8934df2d7c5/gnl-09-805f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c966/4625712/7de4a31177c2/gnl-09-805f3.jpg

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本文引用的文献

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Patient-derived xenograft models to improve targeted therapy in epithelial ovarian cancer treatment.患者来源的异种移植模型用于改善上皮性卵巢癌治疗中的靶向治疗。
Front Oncol. 2013 Dec 4;3:295. doi: 10.3389/fonc.2013.00295.
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New cast for a new era: preclinical cancer drug development revisited.新时代的新选择：重新审视癌症临床前药物研发。
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建立和维护一个广泛的患者来源异种移植模型库。
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Clin Transl Oncol. 2010 Jul;12(7):473-80. doi: 10.1007/s12094-010-0540-6.
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Targeted therapy in biliary tract cancer: 2009 update.胆管癌的靶向治疗：2009 年更新。
Future Oncol. 2009 Dec;5(10):1675-84. doi: 10.2217/fon.09.130.
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Phenotypic instability of Saos-2 cells in long-term culture.
Biochem Biophys Res Commun. 2005 Jul 22;333(1):216-22. doi: 10.1016/j.bbrc.2005.05.097.
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Int J Oncol. 2003 Nov;23(5):1293-300.
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Biologically relevant orthotopic neuroblastoma xenograft models: primary adrenal tumor growth and spontaneous distant metastasis.具有生物学相关性的原位神经母细胞瘤异种移植模型：原发性肾上腺肿瘤生长和自发性远处转移。
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