胸腔积液中细胞角蛋白 19 片段/癌胚抗原比值是检测恶性胸膜间皮瘤的有用标志物。

Cytokeratin 19 fragment/carcinoembryonic antigen ratio in pleural effusion is a useful marker for detecting malignant pleural mesothelioma.

机构信息

Department of Thoracic Malignancy, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, Osaka, Japan.

出版信息

Anticancer Res. 2010 Oct;30(10):4343-6.

PMID:21036761

Abstract

BACKGROUND

The clinical utility of tumour markers in pleural effusion is still controversial with regard to the efficient detection of malignant pleural mesothelioma (MPM).

PATIENTS AND METHODS

The levels of carcinoembryonic antigen (CEA) and cytokeratin 19 fragment (CYFRA 21-1) were retrospectively studied in pleural effusion of unknown origin in patients who had undergone medical thoracoscopy under local anaesthesia.

RESULTS

The study included 134 patients (103 men and 31 women); among them, 33 had MPM. The level of pleural effusion CYFRA 21-1 and the CYFRA 21-1/CEA ratio were significantly different between MPM and other diseases (p<0.01). The sensitivity and specificity of the pleural effusion CYFRA 21-1/CEA ratio were 84.8% and 80.2%, respectively, when the CYFRA 21-1/CEA ratio cut-off value determined by receiver operating characteristic curve analysis was 19.1.

CONCLUSION

MPM should be suspected when the CYFRA 21-1/CEA ratio in pleural effusion is greater than 19.1.

摘要

背景

肿瘤标志物在胸腔积液中的临床应用仍存在争议，尤其是在高效检测恶性胸膜间皮瘤（MPM）方面。

患者和方法

对接受局部麻醉下内科胸腔镜检查的不明原因胸腔积液患者的胸腔积液癌胚抗原（CEA）和细胞角蛋白 19 片段（CYFRA 21-1）水平进行回顾性研究。

结果

本研究共纳入 134 例患者（103 名男性和 31 名女性）；其中 33 例为 MPM。胸腔积液 CYFRA 21-1 水平和 CYFRA 21-1/CEA 比值在 MPM 和其他疾病之间存在显著差异（p<0.01）。通过受试者工作特征曲线分析确定的 CYFRA 21-1/CEA 比值截断值为 19.1 时，胸腔积液 CYFRA 21-1/CEA 比值的敏感性和特异性分别为 84.8%和 80.2%。