Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Anticancer Res. 2010 Oct;30(10):4347-52.
The aim of this study was to determine if the disease-free interval after initial surgical resection has any useful prognostic value for recurrent endometrial carcinoma patients.
Between 1998 and 2007, complete resection of endometrial carcinoma was achieved in 536 cases at the Departments of Obstetrics and Gynecology of the Osaka University and Osaka Rosai Hospitals of Osaka, Japan. Clinical characteristics of these cases were retrospectively reviewed.
Recurrence was subsequently detected in 54 cases. Overall survival after recurrence in 27 patients with recurrences earlier than 12 months who received no postoperative therapy, radiation, and chemotherapy as an adjuvant therapy were significantly shorter than that of those with recurrences later than 12 months with similar treatments. Multivariate analysis demonstrated that the disease-free interval was an independent factor for prognosis.
We demonstrate a significantly worse prognosis in cases with early versus late recurrence of resected endometrial carcinomas, irrespective of the type of adjuvant therapy.
本研究旨在确定初始手术切除后无疾病间期对复发性子宫内膜癌患者是否具有有用的预后价值。
1998 年至 2007 年间，日本大阪大学和大阪癌症研究所妇产科完成了 536 例子宫内膜癌的完全切除术。回顾性分析了这些病例的临床特征。
随后在 54 例中发现复发。在未接受术后治疗、放疗和化疗作为辅助治疗的 27 例 12 个月内复发的患者中，复发后总生存率明显短于接受类似治疗的 12 个月后复发的患者。多因素分析表明，无疾病间期是预后的独立因素。
我们证明了无论辅助治疗类型如何，与晚期复发相比，早期复发的子宫内膜癌患者预后明显较差。
