Comprehensive Laboratory, Third Affiliated Hospital of Suzhou University, Jiangsu, Changzhou , China.
Anticancer Res. 2010 Oct;30(10):4363-8.
Matrix metalloproteinases (MMPs) play an important role in the pathological processes of degradation of extracellular matrix and destruction of basement membrane, which leads to tumor invasion and metastasis. In the present study, we investigated membrane-type 2 MMP (MT2-MMP) expression pattern in esophageal cancer tissues collected from 103 patients, and explored MT2-MMP expression pattern in correlation to patients' clinicopathological features, intratumoral angiogenesis and postoperative prognoses. The intensity of immunochemical staining of MT2-MMP was significantly positively correlated to the intratumoral angiogenesis of esophageal cancer tissues. Positive MT2-MMP immunoreactions were found in 85.4% of total tumor sections, whereas none or very weak MT2-MMP staining occurred in normal esophageal tissues. In addition, MT2-MMP immunochemical intensities were significantly correlated to tumor size, but not to patient's gender, age, invasion depth, lymph node metastasis and distant metastasis. Moreover, MT2-MMP levels could not be applied for predicting patients' survival rate although the H-score cut-off value showed the overall survival rate of patients with low MT2-MMP protein level to be better than those with high MT2-MMP protein level.
基质金属蛋白酶（MMPs）在细胞外基质降解和基底膜破坏的病理过程中发挥重要作用，导致肿瘤侵袭和转移。本研究通过检测 103 例食管癌组织中膜型 2 基质金属蛋白酶（MT2-MMP）的表达模式，探讨 MT2-MMP 与患者临床病理特征、肿瘤内血管生成及术后预后的关系。MT2-MMP 的免疫化学染色强度与食管癌组织内的血管生成呈显著正相关。在所有肿瘤切片中，有 85.4%呈现阳性 MT2-MMP 免疫反应，而正常食管组织中则无或仅有微弱的 MT2-MMP 染色。此外，MT2-MMP 的免疫化学强度与肿瘤大小显著相关，但与患者性别、年龄、浸润深度、淋巴结转移和远处转移无关。此外，尽管 H 评分截断值显示低 MT2-MMP 蛋白水平患者的总生存率优于高 MT2-MMP 蛋白水平患者，但 MT2-MMP 水平不能用于预测患者的生存率。
