Gregoratto D, Bailey M R, Marsh J W
Radiation Protection Division, Health Protection Agency, Chilton, Didcot, Oxon OX11 0RQ, UK.
Radiat Prot Dosimetry. 2011 Mar;144(1-4):353-6. doi: 10.1093/rpd/ncq314. Epub 2010 Oct 29.
New information on particle retention of inhaled insoluble material indicates that the ICRP Human Respiratory Tract Model (HRTM) significantly underestimates long-term retention in the lungs. In a previous paper, the information from three studies was reviewed, and a model developed to predict particle retention in the lungs of coal miners was adapted in order to obtain parameter values for general use to predict particle retention in the alveolar-interstitial (AI) region. The model is physiologically based and simpler than the HRTM, requiring two instead of three compartments to model the AI region. The main difference from the HRTM AI model is that a significant fraction, about 35 %, of the AI deposit of insoluble material remains sequestered in the interstitium. The new model is here applied to the analysis of two well-known contamination cases with several years of follow-up data.
关于吸入不溶性物质的颗粒滞留的新信息表明，国际辐射防护委员会（ICRP）的人类呼吸道模型（HRTM）显著低估了肺部的长期滞留情况。在之前的一篇论文中，对三项研究的信息进行了综述，并对一个用于预测煤矿工人肺部颗粒滞留的模型进行了调整，以便获得一般用于预测肺泡-间质（AI）区域颗粒滞留的参数值。该模型基于生理学原理，比HRTM更简单，对AI区域建模只需两个而非三个隔室。与HRTM的AI模型的主要区别在于，不溶性物质在AI区域的沉积物中有很大一部分（约35%）仍滞留在间质中。新模型在此应用于对两个有多年随访数据的著名污染案例的分析。
