Robasky Kimberly, Bulyk Martha L
Department of Medicine, Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Nucleic Acids Res. 2011 Jan;39(Database issue):D124-8. doi: 10.1093/nar/gkq992. Epub 2010 Oct 30.
The Universal PBM Resource for Oligonucleotide-Binding Evaluation (UniPROBE) database is a centralized repository of information on the DNA-binding preferences of proteins as determined by universal protein-binding microarray (PBM) technology. Each entry for a protein (or protein complex) in UniPROBE provides the quantitative preferences for all possible nucleotide sequence variants ('words') of length k ('k-mers'), as well as position weight matrix (PWM) and graphical sequence logo representations of the k-mer data. In this update, we describe >130% expansion of the database content, incorporation of a protein BLAST (blastp) tool for finding protein sequence matches in UniPROBE, the introduction of UniPROBE accession numbers and additional database enhancements. The UniPROBE database is available at http://uniprobe.org.
寡核苷酸结合评估通用PBM资源（UniPROBE）数据库是一个集中式信息库，包含通过通用蛋白质结合微阵列（PBM）技术确定的蛋白质DNA结合偏好信息。UniPROBE中每个蛋白质（或蛋白质复合物）条目提供了长度为k（“k聚体”）的所有可能核苷酸序列变体（“单词”）的定量偏好，以及k聚体数据的位置权重矩阵（PWM）和图形序列标志表示。在本次更新中，我们描述了数据库内容扩充超130%，纳入了用于在UniPROBE中查找蛋白质序列匹配项的蛋白质BLAST（blastp）工具，引入了UniPROBE登录号以及其他数据库增强功能。可通过http://uniprobe.org访问UniPROBE数据库。
