UniPROBE 2011年更新：蛋白质 - DNA相互作用的蛋白质结合微阵列数据在线数据库中的内容和搜索工具得到扩展。
UniPROBE, update 2011: expanded content and search tools in the online database of protein-binding microarray data on protein-DNA interactions.
作者信息
Robasky Kimberly, Bulyk Martha L
机构信息
Department of Medicine, Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
出版信息
Nucleic Acids Res. 2011 Jan;39(Database issue):D124-8. doi: 10.1093/nar/gkq992. Epub 2010 Oct 30.
The Universal PBM Resource for Oligonucleotide-Binding Evaluation (UniPROBE) database is a centralized repository of information on the DNA-binding preferences of proteins as determined by universal protein-binding microarray (PBM) technology. Each entry for a protein (or protein complex) in UniPROBE provides the quantitative preferences for all possible nucleotide sequence variants ('words') of length k ('k-mers'), as well as position weight matrix (PWM) and graphical sequence logo representations of the k-mer data. In this update, we describe >130% expansion of the database content, incorporation of a protein BLAST (blastp) tool for finding protein sequence matches in UniPROBE, the introduction of UniPROBE accession numbers and additional database enhancements. The UniPROBE database is available at http://uniprobe.org.
寡核苷酸结合评估通用PBM资源（UniPROBE）数据库是一个集中式信息库，包含通过通用蛋白质结合微阵列（PBM）技术确定的蛋白质DNA结合偏好信息。UniPROBE中每个蛋白质（或蛋白质复合物）条目提供了长度为k（“k聚体”）的所有可能核苷酸序列变体（“单词”）的定量偏好，以及k聚体数据的位置权重矩阵（PWM）和图形序列标志表示。在本次更新中，我们描述了数据库内容扩充超130%，纳入了用于在UniPROBE中查找蛋白质序列匹配项的蛋白质BLAST（blastp）工具，引入了UniPROBE登录号以及其他数据库增强功能。可通过http://uniprobe.org访问UniPROBE数据库。
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