Mertz D P, Suermann I, Göhmann E
MMW Munch Med Wochenschr. 1978 Aug 25;120(34):1097-9.
After changing over from the usual eating habits to a "reasonable" restricted diet rich in polyene saturated fats and saturated fatty acids, additional treatment with 1 g clofibrate twice daily produces a significant reduction of concentration of total cholesterol and Apo B by about 24% in the serum of patients with Type IIa hyperlipoproteinemia after 2 weeks. In contrast to this the serum concentration of triglycerides and phospholipids shows an insignificant tendency to fall during the whole duration of the trial. The results suggest that the additional cholesterol reducing action of clofibrate in patients with hyperlipoproteinemia Type IIa who have already been treated by diet is mainly achieved by the reduction of LDL-cholesterol, the atherogenic properties of which are well known.
在从通常的饮食习惯转变为富含多烯饱和脂肪和饱和脂肪酸的“合理”限制饮食后，对于IIa型高脂蛋白血症患者，每日两次额外服用1克氯贝丁酯，2周后血清中总胆固醇和载脂蛋白B的浓度显著降低约24%。与此形成对比的是，在整个试验期间，甘油三酯和磷脂的血清浓度呈现出不显著的下降趋势。结果表明，氯贝丁酯对已接受饮食治疗的IIa型高脂蛋白血症患者的额外降胆固醇作用，主要是通过降低低密度脂蛋白胆固醇来实现的，其致动脉粥样硬化特性是众所周知的。
