Mertz D P, Suermann I, Göhmann E
Med Klin. 1979 Feb 23;74(8):279-83.
If patients with hyperlipoproteinemia type IIa are treated with diet and additionally over a period of two weeks with 2 grams of Clofibrate daily, the cholesterol-level in the serum decreases. This decrease is caused mainly by a reduction of the apolipoprotein B and the LDL-cholesterol in serum. If elevated cholesterol-levels in the serum are reduced through a "prudent" diet, the concentration of apolipoprotein B in serum remains the same. It is not fully understood which influence a diet, which is rich in poly-unsaturated fatty acids and has a low content of saturated fatty acids and carbohydrates, has upon the lipoproteins in the serum. The mode of action of this diet and its significance for the concentration of HDL need further investigation.
如果IIa型高脂蛋白血症患者接受饮食治疗，并在两周内每天额外服用2克氯贝丁酯，血清中的胆固醇水平会降低。这种降低主要是由于血清中载脂蛋白B和低密度脂蛋白胆固醇的减少所致。如果通过“谨慎”饮食降低血清中升高的胆固醇水平，血清中载脂蛋白B的浓度保持不变。富含多不饱和脂肪酸、饱和脂肪酸和碳水化合物含量低的饮食对血清中的脂蛋白有何种影响尚不完全清楚。这种饮食的作用方式及其对高密度脂蛋白浓度的意义需要进一步研究。
