十二指肠溃疡愈合以及对改良假饲和五肽胃泌素刺激的胃酸分泌反应。

Duodenal ulcer healing and acid secretory responses to modified sham feeding and pentagastrin stimulation.

作者信息

Johnston D A, Marks I N, Young G O, Tigler-Wybrandi N A, Bridger S

机构信息

Department of Medicine, University of Cape Town & Groote Schuur Hospital, Cape Town, South Africa.

出版信息

Aliment Pharmacol Ther. 1990 Aug;4(4):403-10. doi: 10.1111/j.1365-2036.1990.tb00486.x.

DOI:10.1111/j.1365-2036.1990.tb00486.x

PMID:2103758

Abstract

The effect of duodenal ulcer healing on the acid secretory responses to modified sham feeding and maximal pentagastrin stimulation has been studied in 17 patients treated successfully with ranitidine (n = 9) and sucralfate (n = 8). Parietal cell sensitivity was calculated as the ratio of the modified sham feeding response to the peak pentagastrin response, expressed as a percentage. Ulcer healing after sucralfate therapy resulted in significant falls in modified sham feeding stimulated acid output (P less than 0.02), from 9.4 (1.8-17.0) (median + range) to 3.7 (0.2-9.4) mmol/h; in peak acid output (P less than 0.05) from 42.8 (23.0-61.4) to 27.7 (7.2-51.0) mmol/h; and in the parietal cell sensitivity (P less than 0.05) from 19.2 (4.4-42.6) to 14.3 (2.8-19.7)%. No significant falls in any of these parameters were noted following ulcer healing with ranitidine. Duodenal ulcer healing with sucralfate results in decreased acid secretory responses to vagal and pentagastrin stimulation.

摘要

对17例分别成功接受雷尼替丁治疗（n = 9）和硫糖铝治疗（n = 8）的患者，研究了十二指肠溃疡愈合对改良假饲及最大五肽胃泌素刺激的胃酸分泌反应的影响。壁细胞敏感性以改良假饲反应与五肽胃泌素峰值反应的比值计算，以百分比表示。硫糖铝治疗后溃疡愈合导致改良假饲刺激的胃酸分泌量显著下降（P<0.02），从9.4（1.8 - 17.0）（中位数+范围）降至3.7（0.2 - 9.4）mmol/h；胃酸分泌峰值显著下降（P<0.05），从42.8（23.0 - 61.4）降至27.7（7.2 - 51.0）mmol/h；壁细胞敏感性显著下降（P<0.05），从19.2（4.4 - 42.6）降至14.3（2.8 - 19.7）%。雷尼替丁治疗溃疡愈合后，这些参数均未出现显著下降。硫糖铝治疗十二指肠溃疡愈合导致对迷走神经和五肽胃泌素刺激的胃酸分泌反应降低。