十二指肠溃疡患者对不同时长假饲的胃分泌及血浆激素反应
Gastric secretory and plasma hormonal responses to sham-feeding of varying duration in patients with duodenal ulcer.
作者信息
Konturek S J, Swierczek J, Kwiecień N, Obtutowicz W, Dobrzańska M, Kopp B, Oleksy J
出版信息
Gut. 1981 Dec;22(12):1003-10. doi: 10.1136/gut.22.12.1003.
Gastric acid and serum gastrin, pancreatic polypeptide, and insulin responses to cephalic vagal stimulation were studied in eight patients with duodenal ulcer using modified sham-feeding for periods varying from four to 30 minutes. In addition, the maximal acid response to sham-feeding was compared with that induced by pentagastrin in 10 healthy subjects and 14 patients with duodenal ulcer. It was found that the gastric acid response to modified sham-feeding reached the maximal value after 15 minutes of sham-feeding and amounted to about 68% of the pentagastrin maximum. The serum pancreatic polypeptide response was also increased after modified sham-feeding and depended on the duration of this procedure, whereas gastrin and insulin responses were not significantly affected by modified sham-feeding. When the peak acid output induced by modified sham-feeding was normalised as percentage of the peak response to pentagastrin, it was similar in healthy subjects and in patients with duodenal ulcer; this indicates that the increased peak acid response to modified sham-feeding observed in patients with duodenal ulcer corresponded with their greater parietal cell mass rather than with increased vagal tone.
采用改良假饲法，对8例十二指肠溃疡患者进行了4至30分钟不等时间的假饲，研究胃酸、血清胃泌素、胰多肽及胰岛素对迷走神经头端刺激的反应。此外，还将10名健康受试者和14例十二指肠溃疡患者假饲引起的最大胃酸反应与五肽胃泌素诱发的胃酸反应进行了比较。结果发现，改良假饲15分钟后，胃酸反应达到最大值，约为五肽胃泌素最大反应值的68%。改良假饲后血清胰多肽反应也增强，且取决于该操作的持续时间，而胃泌素和胰岛素反应未受改良假饲的显著影响。当将改良假饲诱发的胃酸峰值输出量按占五肽胃泌素峰值反应的百分比进行标准化后，健康受试者和十二指肠溃疡患者的该值相似；这表明，十二指肠溃疡患者中观察到的改良假饲引起的胃酸峰值反应增加与其壁细胞数量增多有关，而非迷走神经张力增加所致。
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