CRUK Biomolecular Structure Group, The School of Pharmacy, University of London, London WC1N 1AX, UK.
Chem Commun (Camb). 2010 Dec 28;46(48):9116-8. doi: 10.1039/c0cc02917c. Epub 2010 Oct 29.
A library of triazole-based telomeric quadruplex-selective ligands has been developed that mimic an established family of tri-substituted acridine-based ligands, using crystal structure data as a starting-point for computer-based design. Binding affinities, estimated by electrospray mass spectrometry, are in accord with the design concept.
已经开发了一种基于三唑的端粒四聚体选择性配体库，该库模拟了一组已建立的三取代吖啶基配体，使用晶体结构数据作为计算机设计的起点。通过电喷雾质谱法估算的结合亲和力与设计概念一致。
