Department of Dermatology, American University of Beirut - Medical Center, Beirut, Lebanon.
Int J Dermatol. 2010 Nov;49(11):1244-9. doi: 10.1111/j.1365-4632.2009.04233.x.
Sweet's syndrome (SS) is an uncommon disorder characterized by the abrupt onset of erythematous papules and plaques that histologically exhibit diffuse dermal neutrophilic infiltrate and edema. There are usually associated constitutional symptoms such as fever, neutrophilia, elevated serum inflammatory markers, and associated disorders. The aim of this study was to assess the clinical and histologic features of all patients diagnosed with SS at our institution between 1971 and 2008 and to compare their findings with those published in the literature.
Retrospective review of 44 cases of SS diagnosed at the American University of Beirut - Medical Center between 1971 and 2008. Data collected included clinical (age, gender, morphology and distribution of lesions, associated symptoms and disorders, therapy) and histologic features, as well as laboratory abnormalities.
Most of our patients showed the typical clinical, histologic, and laboratory abnormalities characteristic of SS. Of our 44 patients, 33 (75%) had classic SS while 11 (25%) had an underlying malignant disorder. Of all patients, 7 (16%) were in the pediatric age group, five (11%) had the neutrophilic dermatosis of the dorsal hands variant of SS and two (5%) had subcutaneous SS. Most patients were treated with a tapering dose of systemic corticosteroids with a good response.
The clinical and histologic findings of the 44 SS patients in our study are generally comparable to those published in the literature, with some differences.
Sweet 综合征（SS）是一种不常见的疾病，其特征为突然出现红斑性丘疹和斑块，组织学表现为弥漫性真皮中性粒细胞浸润和水肿。通常伴有全身症状，如发热、中性粒细胞增多、血清炎症标志物升高和相关疾病。本研究旨在评估 1971 年至 2008 年间在我院诊断为 SS 的所有患者的临床和组织学特征，并将其结果与文献中的结果进行比较。
回顾性分析 1971 年至 2008 年间在贝鲁特美国大学医学中心诊断为 SS 的 44 例病例。收集的数据包括临床（年龄、性别、病变形态和分布、相关症状和疾病、治疗）和组织学特征以及实验室异常。
我们的大多数患者表现出典型的临床、组织学和实验室异常，符合 SS 的特征。在我们的 44 例患者中，33 例（75%）为典型 SS，11 例（25%）为潜在恶性疾病。所有患者中，有 7 例（16%）为儿科年龄组，5 例（11%）为 SS 的背部手部中性粒细胞皮肤病变异型，2 例（5%）为皮下 SS。大多数患者接受了递减剂量的全身皮质类固醇治疗，反应良好。
我们的研究中 44 例 SS 患者的临床和组织学发现与文献中的结果大致相似，但也存在一些差异。
