Fett D L, Gibson L E, Su W P
Department of Dermatology, Mayo Clinic Rochester, MN 55905.
Mayo Clin Proc. 1995 Mar;70(3):234-40. doi: 10.4065/70.3.234.
To characterize the findings associated with acute febrile neutrophilic dermatosis (Sweet's syndrome [SS]) and the response of SS to treatment.
We retrospectively reviewed 48 cases of SS encountered at the Mayo Clinic between 1980 and 1992.
Histopathologic specimens and medical records were studied to determine initial manifestations, patterns of involvement, systemic signs and symptoms (including mucosal, musculoskeletal, hematologic, pulmonary, hepatic, and renal findings), and conditions associated with SS.
In patients with SS, the typical manifestations are the acute onset of tender, erythematous or violaceous nodules or plaques in association with fever, leukocytosis, and dermal neutrophilia. In our study group, the cutaneous lesions most frequently involved the arms and legs. Of our 48 patients, 26 (54%) had a hematopoietic, plasma cell, or malignant disorder, and many of these patients had associated anemia, especially the male patients. No single laboratory finding specifically indicated an association with serious systemic disease. Most patients were treated with a tapering dose of prednisone, which yielded a good response.
Clinical acumen and appropriate laboratory tests are the main requirements for detection of hematologic disorders, internal malignant diseases, or other systemic conditions associated with SS.
描述与急性发热性嗜中性皮病（Sweet综合征[SS]）相关的发现以及SS对治疗的反应。
我们回顾性分析了1980年至1992年间在梅奥诊所遇到的48例SS病例。
研究组织病理学标本和病历，以确定初始表现、受累模式、全身体征和症状（包括黏膜、肌肉骨骼、血液、肺部、肝脏和肾脏的表现）以及与SS相关的情况。
SS患者的典型表现为伴有发热、白细胞增多和真皮嗜中性粒细胞增多的压痛性、红斑或紫红色结节或斑块急性发作。在我们的研究组中，皮肤病变最常累及手臂和腿部。在我们的48例患者中，26例（54%）患有造血、浆细胞或恶性疾病，其中许多患者伴有贫血，尤其是男性患者。没有单一的实验室检查结果能明确表明与严重全身性疾病有关。大多数患者接受了逐渐减量的泼尼松治疗，效果良好。
临床敏锐度和适当的实验室检查是检测与SS相关的血液系统疾病、内部恶性疾病或其他全身性疾病的主要要求。
