Skin Bullous Diseases Research Center, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Int J Dermatol. 2010 Nov;49(11):1261-5. doi: 10.1111/j.1365-4632.2010.04515.x.
Pemphigus is an autoimmune disorder, which results from interaction of exogenous and endogenous factors. One of these environmental factors is viral infections particularly, herpesviruses. We aimed to detect the presence of HSV 1 and 2 (herpes simplex virus) and HHV8 (human herpesvirus 8) in our patients who were suffering from pemphigus vulgaris.
In this cross-sectional study, 38 patients (19 male and 19 female patients) with pemphigus vulgaris were entered, 32 skins and six peripheral blood cells samples were obtained from the study population. Thereafter, the presence of HHV8 and HSV DNA were evaluated by using polymerase chain reaction (PCR).
The mean age of patients was 45.05 ± 17.24 years (range: 16-81 years). Twelve patients mentioned history of herpes labial in the past (31.57%). Results of PCR test for detection of HSV and HHV8 DNA in all 32 skin samples and five peripheral blood samples and one case with skin and blood samples were reported negative.
Inability to detect HHV8 and HSV DNA in this study suggests that herpesviruses may be only occasional factors for development or exacerbation of pemphigus vulgaris.
天疱疮是一种自身免疫性疾病，由外源性和内源性因素相互作用引起。这些环境因素之一是病毒感染，特别是疱疹病毒。我们旨在检测患有寻常型天疱疮的患者中单纯疱疹病毒 1 和 2（单纯疱疹病毒）和 HHV8（人类疱疹病毒 8）的存在。
在这项横断面研究中，纳入了 38 名寻常型天疱疮患者（19 名男性和 19 名女性患者），从研究人群中获得了 32 份皮肤样本和 6 份外周血样本。然后，通过聚合酶链反应（PCR）评估 HHV8 和 HSV DNA 的存在。
患者的平均年龄为 45.05 ± 17.24 岁（范围：16-81 岁）。12 名患者在过去曾提到过唇疱疹病史（31.57%）。对所有 32 份皮肤样本和 5 份外周血样本以及 1 份皮肤和血液样本进行的 PCR 检测结果均为 HSV 和 HHV8 DNA 阴性。
本研究未能检测到 HHV8 和 HSV DNA，这表明疱疹病毒可能只是寻常型天疱疮发展或恶化的偶发因素。
