Miliţă Nicoleta Manuela, Mihăescu Gr, Chifiriuc Carmen
Direcţia Sanitară Veterinară şi pentru Siguranţa Alimentelor Bucureşti.
Bacteriol Virusol Parazitol Epidemiol. 2010 Jan-Mar;55(1):19-24.
Aflatoxins are secondary metabolites produced by a group of strains, mainly Aspergillus and Penicillium species. These mycotoxins are bifurano-coumarin derivatives group with four major products B1, B2, G1 and G2 according to blue or green fluorescence emitted in ultraviolet light and according to chromatographic separation. After metabolism of aflatoxin B1 and B2 in the mammalian body, result two metabolites M1 and M2 as hydroxylated derivatives of the parent compound. Aflatoxins have high carcinogenic potential, the most powerful carcinogens in different species of animals and humans. International Agency for Research on Cancer has classified aflatoxin B1 in Group I carcinogens. The target organ for aflatoxins is the liver. In chronic poisoning, aflatoxin is a risk to health, for a long term causing cancer (hepatocellular carcinoma), and in acute intoxications aflatoxin is lethal. This work purpose to discuss aflatoxins issue: the synthesis, absorption and elimination of aflatoxins, the toxicity mechanisms, and measures to limit the content of aflatoxins in food
黄曲霉毒素是由一组菌株产生的次生代谢产物，主要是曲霉属和青霉属物种。这些霉菌毒素是双呋喃香豆素衍生物组，根据在紫外线下发出的蓝色或绿色荧光以及色谱分离，有四种主要产物B1、B2、G1和G2。黄曲霉毒素B1和B2在哺乳动物体内代谢后，产生两种代谢产物M1和M2，作为母体化合物的羟基化衍生物。黄曲霉毒素具有很高的致癌潜力，是不同动物和人类物种中最强大的致癌物。国际癌症研究机构已将黄曲霉毒素B1归类为I类致癌物。黄曲霉毒素的靶器官是肝脏。在慢性中毒中，黄曲霉毒素对健康构成风险，长期会导致癌症（肝细胞癌），而在急性中毒中，黄曲霉毒素是致命的。这项工作旨在讨论黄曲霉毒素问题：黄曲霉毒素的合成、吸收和消除、毒性机制以及限制食品中黄曲霉毒素含量的措施
