Department of Neurology, Sahlgrenska University Hospital, Göteborg, Sweden.
Acta Neurol Scand. 2011 Sep;124(3):206-10. doi: 10.1111/j.1600-0404.2010.01451.x. Epub 2010 Oct 29.
Cerebrospinal fluid (CSF) levels of neurofilament triplet protein (NFL), a non-specific marker of neuronal damage, are normal in Parkinson's disease (PD) but increased after brain trauma and in several neurological disorders. Using longitudinal CSF-NFL measurements as an indicator of neuronal damage, this study investigated the impact of deep brain stimulation (DBS) of the subthalamic nucleus (STN) on the brain, directly following the surgical intervention and in chronically treated patients with PD.
CSF-NFL levels were measured consecutively in eight patients with PD before and after STN-DBS treatment.
CSF-NFL levels were normal prior to STN-DBS and increased sharply during the first 2 weeks post-operatively, but normalized after 12 months or more.
The STN-DBS procedure leads to an acute but limited neuronal damage, as expected. However, normal CSF-NFL levels at 12 months post-operatively and beyond suggest the absence of any long-term neuronal damage caused by long-term STN-DBS stimulation.
神经丝三联蛋白（NFL）是神经元损伤的非特异性标志物，其脑脊液（CSF）水平在帕金森病（PD）中正常，但在脑外伤后和几种神经疾病中升高。本研究使用纵向 CSF-NFL 测量作为神经元损伤的指标，直接在手术干预后和慢性 PD 患者中，研究了丘脑底核（STN）深部脑刺激（DBS）对大脑的影响。
连续测量了 8 例 PD 患者在 STN-DBS 治疗前后的 CSF-NFL 水平。
在 STN-DBS 之前，CSF-NFL 水平正常，术后 2 周内急剧升高，但 12 个月或更长时间后恢复正常。
STN-DBS 手术导致预期的急性但有限的神经元损伤。然而，术后 12 个月及以后 CSF-NFL 水平正常表明，长期 STN-DBS 刺激不会引起任何长期的神经元损伤。
