Institut für Psychologie, Humboldt-Universität zu Berlin, Berlin, Germany.
Psychophysiology. 2011 Jun;48(6):755-61. doi: 10.1111/j.1469-8986.2010.01138.x. Epub 2010 Oct 29.
Obsessive-compulsive disorder (OCD) patients show deficits in tasks of executive functioning like the antisaccade (AS) task. These deficits suggest problems in response inhibition or volitional saccade generation. Thirty patients (15 nonmedicated) and 30 healthy subjects performed antisaccades and simple volitional saccades (SVS), that is, centrally cued saccades. In SVS, two aspects of volitional saccade generation were disentangled: response selection and initiation. Latencies of OCD patients were increased in volitional saccades independent of response selection demands. AS performance did not differ. Across groups, latencies in AS were faster than in SVS. Medicated patients did not differ from nonmedicated patients. In sum, response initiation is deficient in OCD patients, which may reflect a general problem in volitional action generation. This deficit did not affect antisaccade performance, possibly due to a lower volitional demand in that task.
强迫症（OCD）患者在执行功能任务（如反扫视任务）中表现出缺陷。这些缺陷表明存在反应抑制或随意扫视生成方面的问题。30 名患者（15 名未服药）和 30 名健康受试者进行了反扫视和简单的随意扫视（SVS），即中央提示扫视。在 SVS 中，随意扫视生成的两个方面被区分开来：反应选择和启动。无论反应选择要求如何，强迫症患者的随意扫视潜伏期都增加了。反扫视表现没有差异。在所有组中，反扫视的潜伏期都快于 SVS。服药患者与未服药患者没有差异。总之，反应启动在 OCD 患者中存在缺陷，这可能反映了随意动作生成的一般问题。这种缺陷并没有影响反扫视表现，可能是因为该任务的随意性要求较低。
