Department of Mycology, Federal University of Pernambuco (UFPE), Recife-PE, Brazil Neurologic Diagnosis Service of Pernambuco, Recife-PE, Brazil.
Lett Appl Microbiol. 2010 Nov;51(5):485-9. doi: 10.1111/j.1472-765X.2010.02914.x.
The in vitro activity of ciclopirox olamine was evaluated against Cryptococcus spp. obtained from the cerebrospinal fluid (CSF) of immunocompromised patients.
The antifungal activity of ciclopirox olamine was tested against Cryptococcus spp. obtained from the CSF of immunocompromised patients, using amphotericin B and fluconazole as controls. The minimal inhibitory concentration was determined following the microdilution method indicated by the Clinical and Laboratory Standards Institute. The minimal fungicide concentration was determined by the absence of growth on Sabouraud dextrose agar. The data obtained showed that antifungal activity of ciclopirox olamine ranged from 0·25 to 1 μg ml(-1) .
This paper underscores the importance of the antifungal potential of ciclopirox olamine against Cryptococcus spp. as an alternative treatment against systemic cryptococosis. In vivo experiments are essential for future medical use.
This was the first time that ciclopirox olamine was tested against Cryptococcus spp. using the reference method. The antifungal activity of this drug against this species suggests an applicable potential for systemic cryptococcosis therapy.
评估环吡酮胺对免疫功能低下患者脑脊液中分离的隐球菌的体外活性。
使用两性霉素 B 和氟康唑作为对照，采用微量稀释法测定环吡酮胺对免疫功能低下患者脑脊液中分离的隐球菌的抗真菌活性。根据临床和实验室标准协会的指示确定最小抑菌浓度。最小杀菌浓度通过在沙氏葡萄糖琼脂上无生长来确定。所得数据表明，环吡酮胺的抗真菌活性范围为 0.25 至 1μg/ml。
本文强调了环吡酮胺对隐球菌的抗真菌潜力作为系统性隐球菌病的替代治疗方法的重要性。未来的医学应用需要进行体内实验。
这是首次使用参考方法测试环吡酮胺对隐球菌的作用。该药物对该种属的抗真菌活性表明其对系统性隐球菌病治疗具有潜在应用价值。
