Abate G, Zito M, Guarino F, Di Peppe M C, Troya C
Istituto di Fisiopatologia Medica, Cattedra di Geriatria, Università degli Studi G. D'Annunzio, Chieti.
Riv Eur Sci Med Farmacol. 1990 Aug-Oct;12(4-5):273-81.
Two groups, each composed of 20 elderly patients suffering from osteoarthritis characterised by intense pain, were treated for 4 weeks with the oral formulation of two modern oxicam derivatives (tenoxicam capsules and beta-cyclodextrin-piroxicam tablets respectively). The analysis of the results showed that both drugs have an excellent antalgic effect. After the first dose the action of beta-cyclodextrin-piroxican was quicker and more marked, with statistically significant differences between treatments for the first 4 hours. At the end of the study period the two drugs proved to be equally effective, with a more pronounced symptomatic effect of beta-cyclodextrin-piroxican. No side effects serious enough to warrant suspension of treatment were observed: the only side effects reported were gastric adverse events (pyrosis, gastralgia) in both groups, having an incidence of 50% (tenoxicam) and 15% (beta-cyclodextrin-piroxicam) respectively.
两组，每组由20名患有以剧痛为特征的骨关节炎的老年患者组成，分别用两种现代奥昔康衍生物的口服制剂（替诺昔康胶囊和β-环糊精吡罗昔康片）治疗4周。结果分析表明，两种药物均具有出色的镇痛效果。首次给药后，β-环糊精吡罗昔康的作用起效更快且更显著，在最初4小时内治疗之间存在统计学显著差异。在研究期结束时，两种药物被证明同样有效，β-环糊精吡罗昔康的症状改善效果更明显。未观察到严重到足以导致停药的副作用：报告的唯一副作用是两组的胃部不良事件（烧心、胃痛），发生率分别为50%（替诺昔康）和15%（β-环糊精吡罗昔康）。
