Department of Clinical Chemistry, Erasmus University Medical Center, Rotterdam, The Netherlands.
Scand J Immunol. 2010 Nov;72(5):444-8. doi: 10.1111/j.1365-3083.2010.02453.x.
Autoimmune pancreatitis (AIP) is associated with a marked elevation of serum total IgG₄ . Although there is evidence of autoimmunity in AIP, there are also signs of an allergic nature of its pathogenesis. Therefore, we determined both IgE and IgG₄ in 13 patients with AIP, in 12 patients with pancreatic carcinoma and in 14 patients with atopic allergy and investigated the relationship between IgE and IgG₄ . Total IgG₄ was determined by automated nephelometry and total IgE by automated enzyme fluoroimmunoassay. Both total IgE and total IgG₄ levels in patients with AIP were significantly higher than those in patients with pancreatic carcinoma (P = 0.0004 and P = 0.015, respectively). There was a significant correlation between the total IgE and total IgG₄ levels in patients with AIP and patients with atopic allergy (r(s) =0.82, P=0.0006 and r(s) =0.88, P < 0.0001, respectively). The IgE/ IgG₄ ratio in sera from patients with atopic allergy was significantly different (P = 0.0012) from this ratio in sera from patients with AIP. These results suggest that analysis of total IgE in serum might be useful in the differentiation between autoimmune pancreatitis and pancreatic carcinoma.
自身免疫性胰腺炎（AIP）与血清总 IgG₄显著升高有关。尽管 AIP 存在自身免疫的证据，但也有其发病机制具有过敏性质的迹象。因此，我们测定了 13 例 AIP 患者、12 例胰腺癌患者和 14 例特应性过敏患者的 IgE 和 IgG₄，并研究了 IgE 和 IgG₄之间的关系。总 IgG₄通过自动散射比浊法测定，总 IgE 通过自动酶荧光免疫法测定。AIP 患者的总 IgG₄和总 IgE 水平均显著高于胰腺癌患者（P=0.0004 和 P=0.015）。AIP 患者和特应性过敏患者的总 IgE 和总 IgG₄水平之间存在显著相关性（r(s)=0.82，P=0.0006 和 r(s)=0.88，P<0.0001）。特应性过敏患者血清中的 IgE/IgG₄ 比值与 AIP 患者血清中的比值显著不同（P=0.0012）。这些结果表明，血清总 IgE 的分析可能有助于区分自身免疫性胰腺炎和胰腺癌。
