Carrero Juan J, Stenvinkel Peter
Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
Semin Dial. 2010 Sep-Oct;23(5):498-509. doi: 10.1111/j.1525-139X.2010.00784.x.
The first reports connecting uremic inflammation with a wasted and atherogenic phenotype and poor outcome initiated in the late 1990s. Since then, about 3500 publications appear on Medline, reflecting the exponential interest that this topic has evoked in nephrology. What was described as a "novel" risk factor 10 years ago has now evolved into an established finding in patients with end-stage renal disease (ESRD). The purpose of this review is to summarize the main advances contributing to our current understanding of the complex inflammatory processes present in ESRD. Causes and consequences of inflammation, genetic heritability of the inflammatory response, implications on outcome prognostication, and contemporary therapeutic evidence are some of the various topics discussed.
关于尿毒症炎症与消瘦、动脉粥样硬化表型及不良预后之间关联的首批报告始于20世纪90年代末。自那时起，医学在线数据库（Medline）上出现了约3500篇相关出版物，反映出该主题在肾脏病学领域引发的指数级兴趣。10年前被描述为“新型”风险因素的内容，如今已发展成为终末期肾病（ESRD）患者的既定发现。本综述的目的是总结有助于我们当前理解ESRD中复杂炎症过程的主要进展。炎症的原因和后果、炎症反应的遗传遗传性、对预后预测的影响以及当代治疗证据等都是所讨论的众多主题中的一部分。
