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2009 年过敏领域的发展——临床与实验过敏的视角。

Developments in the field of allergy in 2009 through the eyes of Clinical and Experimental Allergy.

机构信息

Department of Medicine, National Jewish Health, Denver, CO, USA.

出版信息

Clin Exp Allergy. 2010 Nov;40(11):1611-31. doi: 10.1111/j.1365-2222.2010.03625.x.

Abstract

In 2009 the journal published in the region of 200 papers including reviews, editorials, opinion pieces and original papers that ran the full gamut of allergic disease. It is instructive to take stock of this output to determine patterns of interest and where the cutting edge lies. We have surveyed the field of allergic disease as seen through the pages of Clinical and Experimental Allergy (CEA) highlighting trends, emphasizing notable observations and placing discoveries in the context of other key papers published during the year. The review is divided into similar sections as the journal. In the field of Asthma and Rhinitis CEA has contributed significantly to the debate about asthma phenotypes and expressed opinions about the cause of intrinsic asthma. It has also added its halfpennyworth to the hunt for meaningful biomarkers. In Mechanisms the considerable interest in T cell subsets including Th17 and T regulatory cells continues apace and the discipline of Epidemiology continues to invoke a steady stream of papers on risk factors for asthma with investigators still trying to explain the post-second world war epidemic of allergic disease. Experimental Models continue to make important contributions to our understanding of pathogenesis of allergic disease and in the Clinical Allergy section various angles on immunotherapy are explored. New allergens continue to be described in the allergens section to make those allergen chips even more complicated. A rich and vibrant year helpfully summarized by some of our associate editors.

摘要

2009 年,该期刊发表了约 200 篇论文,包括综述、社论、观点文章和原始论文,涵盖了过敏疾病的各个方面。对这些成果进行评估,以确定关注的模式和前沿领域,这是很有启发性的。我们通过《临床与实验过敏》(Clinical and Experimental Allergy,CEA)的页面来观察过敏疾病领域,强调趋势、突出显著的观察结果,并将发现置于当年发表的其他关键论文的背景下。该综述分为与期刊类似的部分。在哮喘和鼻炎领域,CEA 对哮喘表型的争论做出了重大贡献,并对特应性哮喘的病因发表了意见。它还为寻找有意义的生物标志物做出了贡献。在机制领域,对 T 细胞亚群(包括 Th17 和 T 调节细胞)的浓厚兴趣仍在继续,流行病学学科继续引用大量关于哮喘危险因素的论文,研究人员仍在努力解释二战后过敏疾病的流行。实验模型继续为我们理解过敏疾病的发病机制做出重要贡献,在临床过敏部分,探索了免疫疗法的各种角度。新的过敏原继续在过敏原部分被描述,以使那些过敏原芯片更加复杂。富有活力的一年由我们的一些副主编进行了有益的总结。

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本文引用的文献

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Is Lamarckian evolution relevant to medicine?
BMC Med Genet. 2010 May 13;11:73. doi: 10.1186/1471-2350-11-73.
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Clin Exp Allergy. 2010 Jan;40(1):32-41. doi: 10.1111/j.1365-2222.2009.03378.x.
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Annu Rev Physiol. 2010;72:495-516. doi: 10.1146/annurev-physiol-021909-135926.
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nsLTP and profilin are allergens in mustard seeds: cloning, sequencing and recombinant production of Sin a 3 and Sin a 4.
Clin Exp Allergy. 2009 Dec;39(12):1929-36. doi: 10.1111/j.1365-2222.2009.03382.x.
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Immunotherapy with a modified birch pollen extract in allergic rhinoconjunctivitis: clinical and immunological effects.
Clin Exp Allergy. 2009 Dec;39(12):1903-9. doi: 10.1111/j.1365-2222.2009.03379.x.
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Practical prebiotics, probiotics and synbiotics for allergists: how useful are they?
Clin Exp Allergy. 2009 Dec;39(12):1801-14. doi: 10.1111/j.1365-2222.2009.03368.x.

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