Singapore Eye Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Microcirculation. 2010 Oct;17(7):495-503. doi: 10.1111/j.1549-8719.2010.00048.x.
To describe a new computer-assisted method to measure retinal vascular caliber over an extended area of the fundus.
Retinal photographs taken from participants of the Singapore Malay Eye Study (n = 3280) were used for this study. Retinal vascular caliber was measured and summarized as central retinal artery equivalent (CRAE) and central retinal vein equivalent (CRVE) using a new semi-automated computer-based program. Measurements were made at the Standard zone (from 0.5 to 1.0 disk diameter) and an Extended zone (from 0.5 to 2.0 disk diameter).
Reliability of retinal vascular caliber measurement was high for the new Extended zone (intraclass correlation coefficients >0.90). Associations of CRAE with blood pressure were identical between the Extended and Standard zones (linear regression coefficient -2.53 vs. -2.61, z-test between the two measurements, p = 0.394). Associations of CRAE and CRVE with other cardiovascular risk factors were similar between measurements in the two zones. The R² of regression models for the Extended zone was slightly higher than that for the Standard zone for both CRAE (R², 0.324 vs. 0.288) and CRVE (R², 0.325 vs. 0.265).
The new measures from Extended zone are comparable with the previous measures, and also more representative of retinal vascular caliber.
描述一种新的计算机辅助方法，用于测量眼底较大区域的视网膜血管口径。
本研究使用了来自新加坡马来人眼研究（n = 3280）参与者的眼底照片。使用一种新的半自动基于计算机的程序测量并总结视网膜血管口径，表现为中央视网膜动脉等效直径（CRAE）和中央视网膜静脉等效直径（CRVE）。测量在标准区（0.5 至 1.0 个视盘直径）和扩展区（0.5 至 2.0 个视盘直径）进行。
新的扩展区视网膜血管口径测量具有较高的可靠性（组内相关系数>0.90）。CRAE 与血压之间的相关性在扩展区和标准区之间是相同的（两种测量方法的线性回归系数-2.53 与-2.61，两者之间的 z 检验，p = 0.394）。CRAE 和 CRVE 与其他心血管危险因素之间的相关性在两个区域的测量中也相似。扩展区回归模型的 R² 略高于标准区的 R²，无论是 CRAE（R²，0.324 与 0.288）还是 CRVE（R²，0.325 与 0.265）。
新的扩展区测量值与之前的测量值具有可比性，并且更能代表视网膜血管口径。
