早产产妇血浆总抗氧化状态
Maternal plasma total antioxidant status in preterm labor.
作者信息
Cinkaya Aysegül, Keskin Hüseyin Levent, Buyukkagnici Umran, Gungor Tayfun, Keskin Esra Aktepe, Avsar Ayse Filiz, Bilge Umit
机构信息
Department of High Risk Pregnancy Laboratory, Zekai Tahir Burak Education and Research Hospital, Ankara, Turkey.
出版信息
J Obstet Gynaecol Res. 2010 Dec;36(6):1185-8. doi: 10.1111/j.1447-0756.2010.01300.x. Epub 2010 Oct 11.
AIM
To investigate the role of oxidative stress and antioxidant status in preterm labor.
METHODS
Twenty-five cases diagnosed with preterm labor were included in the study group, whereas 25 women with uncomplicated pregnancies at similar stages of pregnancy were included in the control group. Total antioxidant status was measured in maternal plasma using a Hitachi 911 auto analyzer and a total antioxidant status kit (Randox Laboratories, UK) in mmol/L.
RESULTS
Mean serum antioxidant status were lower in patients (1.002 ± 0.177 mmol/L) than in controls (1.258 ± 0.147 mmol/L) (P < 0.001).
CONCLUSION
Women with preterm labor have decreased total antioxidant status compared with uncomplicated pregnancies in similar gestational weeks. Future work should clarify whether decreased total antioxidant status precedes preterm labor in a prospective cohort study.
目的
探讨氧化应激和抗氧化状态在早产中的作用。
方法
研究组纳入25例诊断为早产的病例，对照组纳入25例妊娠阶段相似且无并发症的孕妇。使用日立911自动分析仪和总抗氧化状态试剂盒（英国兰道夫实验室）以毫摩尔/升为单位测量母体血浆中的总抗氧化状态。
结果
患者的平均血清抗氧化状态（1.002±0.177毫摩尔/升）低于对照组（1.258±0.147毫摩尔/升）（P<0.001）。
结论
与妊娠周数相似的无并发症妊娠妇女相比，早产妇女的总抗氧化状态降低。未来的研究应在前瞻性队列研究中明确总抗氧化状态降低是否先于早产发生。
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