Rehfeld Jens F, Friis-Hansen Lennart, Gøtze Jens Peter, Hilsted Linda, Nielsen Finn Cilius
Klinisk Biokemisk Afdeling (KB3014), Rigshospitalet, 2100 København Ø, Denmark.
Ugeskr Laeger. 2010 Oct 25;172(43):2957-60.
Neuroendocrine tumours of the gastrointestinal tract are rare, but challenging. In addition, they are models in tumour biology. The biochemistry used for diagnosis and control of the therapy has expanded considerably over the past decades. Today, the diagnosis comprises examination of genes in hereditary tumour syndromes as well as measurement of protein markers and specific peptide hormones in a biogenetic context. The infrequency and demand for analytical know-how make the case for centralization of diagnostic examinations.
胃肠道神经内分泌肿瘤较为罕见，但颇具挑战性。此外，它们还是肿瘤生物学的研究模型。在过去几十年里，用于诊断和治疗控制的生物化学方法有了很大扩展。如今，诊断包括对遗传性肿瘤综合征中的基因进行检测，以及在生物发生背景下测量蛋白质标志物和特定肽类激素。由于病例罕见且对分析技术有要求，因此有必要对诊断检查进行集中化管理。
