Monash Alfred Psychiatry Research Centre, The Alfred & Monash University School of Psychology and Psychiatry, Melbourne, Victoria, Australia.
Brain Res. 2011 Jan 12;1368:222-30. doi: 10.1016/j.brainres.2010.10.089. Epub 2010 Oct 30.
While hippocampal volumes have been extensively examined in neuropsychiatric disorders and ageing, small areas of signal variation within the hippocampus commonly observed on MRI, described as hippocampal sulcal cavities (HSCs), have received less attention. We review the published literature on HSCs to examine their prevalence, putative aetiological factors such as hypertension, and possible cognitive correlates. HSCs were reported in 77% (66% weighted mean) of patients with memory disorders and 48% (47% weighted mean) of controls, and the prevalence increased with age in healthy subjects (r=0.64, p=0.047). A number of studies reported hypertension as a risk factor, and related their presence to poorer memory function. Further work is needed to fully understand the clinical significance of these lesions.
虽然海马体体积在神经精神疾病和衰老中已经被广泛研究，但 MRI 上常见的海马体内部小区域信号变化（被描述为海马沟裂），却受到较少关注。我们回顾了有关海马沟裂的已发表文献，以探讨其患病率、高血压等潜在病因因素，以及可能的认知相关性。在记忆障碍患者中，77%（66%加权平均值）和对照组中 48%（47%加权平均值）的患者报告有海马沟裂，且在健康受试者中，患病率随年龄增长而增加（r=0.64，p=0.047）。许多研究报告高血压是一个风险因素，并将其存在与较差的记忆功能相关联。需要进一步的研究来充分了解这些病变的临床意义。
