Swain D G, Ellis D J, Bradby H
Department of Medicine, Sandwell District General Hospital, Lyndon, West Midlands, UK.
Aliment Pharmacol Ther. 1990 Feb;4(1):43-8. doi: 10.1111/j.1365-2036.1990.tb00447.x.
One hundred patients for endoscopy, aged, between 18 and 74 years were randomly allocated to two equal groups. Group A received 10 mg diazepam intravenously rapidly over 2-4 s; Group B received diazepam intravenously over 1-2 min, titrated to provide a satisfactory level of sedation (mean dose 15.9 mg). Patient co-operation during endoscopy was similar in both groups, but one patient in Group A developed respiratory depression. Tests of psychomotor function after endoscopy showed greater impairment 30 min following injection for Group B, compared with Group A (P less than 0.02). Total or partial amnesia for endoscopy was present in 62% of Group A, and 90% in Group B (P less than 0.005). However, postal follow-up showed that endoscopy was acceptable to 96% of Group A and 98% of Group B. Delayed sedation later in the day was reported by 26% of Group A compared with 48% of Group B.
100名年龄在18至74岁之间接受内镜检查的患者被随机分为两组，每组人数相等。A组在2至4秒内快速静脉注射10毫克地西泮；B组在1至2分钟内静脉注射地西泮，并根据情况调整剂量以达到满意的镇静水平（平均剂量15.9毫克）。两组患者在内镜检查期间的配合情况相似，但A组有1名患者出现呼吸抑制。内镜检查后对精神运动功能的测试显示，与A组相比，B组在注射后30分钟时的功能损害更严重（P小于0.02）。A组62%的患者对内镜检查完全或部分失忆，B组为90%（P小于0.005）。然而，随访结果显示，A组96%的患者和B组98%的患者认为内镜检查是可以接受的。A组26%的患者报告当天晚些时候出现延迟镇静，而B组为48%。
