Coghlan J, Hutchinson L, Gilligan D, McKenna D, Keane C, Sweeney E, O'Morain C
Department of Gastroenterology, Meath Hospital, Dublin, Republic of Ireland.
Aliment Pharmacol Ther. 1990 Feb;4(1):49-54. doi: 10.1111/j.1365-2036.1990.tb00448.x.
Sixty consecutive patients with endoscopically proven duodenal ulcers were given colloidal bismuth subcitrate tablets either as 120 mg q.d.s. or 240 mg b.d., in a randomized single-blind study. The efficacy of each regimen was determined by endoscopic examination and antral biopsy at 4 weeks; if the ulcer remained unhealed, treatment was continued and endoscopy repeated at 8 weeks. The ulcer-healing efficacy of the two regimens was identical; however, in the four times daily group only 27% remained Campylobacter pylori positive after 8 weeks of treatment compared with 58% of the twice-daily group. Similarly, only 21% of twice daily patients were free of histological gastritis compared with 42% of the four times daily patients.
在一项随机单盲研究中，60例经内镜证实为十二指肠溃疡的连续患者，分别给予枸橼酸铋钾片，剂量为每日4次，每次120毫克，或每日2次，每次240毫克。在4周时通过内镜检查和胃窦活检确定每种治疗方案的疗效；如果溃疡仍未愈合，则继续治疗，并在8周时重复内镜检查。两种治疗方案的溃疡愈合疗效相同；然而，每日4次给药组在治疗8周后仅27%的患者幽门螺杆菌仍为阳性，而每日2次给药组为58%。同样，每日2次给药的患者中只有21%没有组织学胃炎，而每日4次给药的患者中这一比例为42%。
