卡波氏肉瘤相关疱疹病毒的分子生物学与相关致癌作用。
Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis.
机构信息
Department of Microbiology, Abramson, Comprehensive Cancer Center, University of Pennsylvania Medical School, Philadelphia, Pennsylvania, USA.
出版信息
Adv Virus Res. 2010;78:87-142. doi: 10.1016/B978-0-12-385032-4.00003-3.
Abstract
Kaposi's Sarcoma-associated Herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is the most recently identified human tumor virus,and is associated with the pathogenesis of Kaposi's sarcoma and two lymphoproliferative disorders known to occur frequently in AIDS patients-primary effusion lymphoma and multicentric Castleman disease. In the 15 years since its discovery, intense studies have demonstrated an etiologic role for KSHV in the development of these malignancies. Here, we review the recent advances linked to understanding KSHV latent and lytic life cycle and the molecular mechanisms of KSHV-mediated oncogenesis in terms of transformation, cell signaling, cell growth and survival, angiogenesis, immune invasion and response to microenvironmental stress, and highlight the potential therapeutic targets for blocking KSHV tumorigenesis.
摘要
卡波济肉瘤相关疱疹病毒（Kaposi's Sarcoma-Associated Herpesvirus，KSHV），也称为人类疱疹病毒 8 型（Human Herpesvirus 8，HHV-8），是最近发现的人类肿瘤病毒，与卡波济肉瘤的发病机制以及两种在艾滋病患者中经常发生的淋巴组织增生性疾病有关，即原发性渗出性淋巴瘤和多中心卡斯特曼病。自发现以来的 15 年中，大量研究表明 KSHV 在这些恶性肿瘤的发生中起病因作用。在这里，我们回顾了与理解 KSHV 潜伏和裂解生命周期以及 KSHV 介导的致癌作用的分子机制相关的最新进展，这些机制涉及转化、细胞信号转导、细胞生长和存活、血管生成、免疫入侵和对微环境压力的反应，并强调了阻断 KSHV 肿瘤发生的潜在治疗靶点。
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