周细胞：血脑屏障对神经退行性变的保护作用？
Pericytes: blood-brain barrier safeguards against neurodegeneration?
机构信息
Vesalius Research Center, KU Leuven, B-3000 Leuven, Belgium.
出版信息
Neuron. 2010 Nov 4;68(3):321-3. doi: 10.1016/j.neuron.2010.10.024.
PMID:21040834
Abstract
The role of pericytes in the control of blood-brain barrier (BBB) integrity has remained enigmatic. In this issue, Bell et al. and two concurrent studies highlight that pericyte loss causes BBB breakdown and hypoperfusion. Remarkably, these vascular changes precede neurodegeneration and cognitive defects in old age.
摘要
周细胞在血脑屏障（BBB）完整性控制中的作用一直是个谜。在本期杂志中，Bell 等人的研究和两项同期研究强调了周细胞缺失会导致 BBB 破裂和灌注不足。值得注意的是，这些血管变化先于老年时的神经退行性变和认知缺陷。
Zotero 插件