Zidarič Tanja, Gradišnik Lidija, Velnar Tomaž
Institute of Biomedical Sciences, Faculty of Medicine, University of Maribor, Maribor, Slovenia.
Department of Neurosurgery, University Medical Center Ljubljana, Ljubljana, Slovenia.
Bosn J Basic Med Sci. 2022 Sep 16;22(5):651-672. doi: 10.17305/bjbms.2021.6943.
The blood-brain barrier (BBB) functions as a highly selective border of endothelial cells, protecting the central nervous system from potentially harmful substances by selectively controlling the entry of cells and molecules, including components of the immune system. To study the BBB properties, find suitable therapies, and identify new drug targets, there is a need to develop representative in vitro BBB models. In this article, we describe the astrocyte roles in the BBB functioning and human in vitro BBB models.
血脑屏障（BBB）作为内皮细胞的高度选择性边界，通过选择性地控制细胞和分子（包括免疫系统的成分）的进入，保护中枢神经系统免受潜在有害物质的侵害。为了研究血脑屏障的特性、找到合适的治疗方法并确定新的药物靶点，需要开发具有代表性的体外血脑屏障模型。在本文中，我们描述了星形胶质细胞在血脑屏障功能中的作用以及人类体外血脑屏障模型。
