综述文章：甲硝唑与肠道厌氧菌

Review article: metronidazole and the anaerobic gut flora.

作者信息

Elliott T S, Stone J W

机构信息

Department of Clinical Microbiology, Queen Elizabeth Hospital, Birmingham, UK.

出版信息

Aliment Pharmacol Ther. 1990 Jun;4(3):227-38. doi: 10.1111/j.1365-2036.1990.tb00467.x.

DOI:10.1111/j.1365-2036.1990.tb00467.x

PMID:2104087

Abstract

Metronidazole is a nitro-imidazole drug which was discovered nearly 30 years ago. Metronidazole has remained the mainstay of anti-anaerobic therapy following a change observation that its activity included anaerobic organisms. The predominant human reservoir of these anaerobic organisms is the gastrointestinal tract. In this review, the anaerobic flora and their pathogenic potential are described. The main characteristics of metronidazole and the role of selective decontamination of the gastrointestinal tract are also discussed.

摘要

甲硝唑是一种硝基咪唑类药物，大约30年前被发现。自从观察到其活性包括对厌氧生物有效后，甲硝唑一直是抗厌氧治疗的主要药物。这些厌氧生物在人体内的主要储存部位是胃肠道。在这篇综述中，描述了厌氧菌群及其致病潜力。还讨论了甲硝唑的主要特性以及胃肠道选择性去污的作用。