Division of Hematology, Department of Medicine, University of Washington, Seattle, WA 98915, USA.
Cell Stem Cell. 2010 Nov 5;7(5):547-8. doi: 10.1016/j.stem.2010.10.006.
In a recent issue of Nature Medicine, Ryan et al. (2010) uncover genetic modifiers of G-CSF responses by hematopoietic progenitors. The authors document a negative role of EGFR signaling and, provided an analogous pathway functions in humans, propose a potential new angle to promote clinical blood stem cell mobilization.
在最近一期的《自然医学》杂志上，Ryan 等人（2010 年）揭示了造血祖细胞中粒细胞集落刺激因子反应的遗传修饰因子。作者证明了 EGFR 信号的负调控作用，如果在人类中存在类似的通路，那么这可能为促进临床血液干细胞动员提供一个新的潜在角度。
