Laboratory of Molecular Vertebrate Embryology, The Rockefeller University, New York, NY 10065, USA.
Cell Stem Cell. 2010 Nov 5;7(5):549-50. doi: 10.1016/j.stem.2010.10.002.
In this issue of Cell Stem Cell, Warren et al. (2010) describe a new methodology, using synthetic mRNA, for efficiently generating iPSCs without compromising genomic integrity. This powerful approach can also be used for directed differentiation of iPSCs, or even for trans-differentiation to generate clinically relevant differentiated cell types.
在本期《细胞—干细胞》杂志中，Warren 等人（2010 年）描述了一种新的方法，使用合成 mRNA 有效地生成 iPS 细胞而不损害基因组完整性。这种强大的方法也可用于 iPS 细胞的定向分化，甚至用于转分化以生成临床上相关的分化细胞类型。
