Klenerová V, Hynie S
Neoplasma. 1978;25(3):337-42.
The enzyme activities of cyclic AMP system in the neuro- and adenohypophyses were studied, immediately after an irradiation by a single whole body exposure of 1600 R, in an attempt to find whether this intervention causes the changes in the responsiveness of the cyclic AMP regulatory system. In the irradiated rats the neurohypophyses revealed a reduced activity of adenylate cyclase, moderately increased activity of phosphodiesterase and slightly decreased activity of protein kinase, including the value stimulated by cyclic AMP. In the adenohypophyses the irradiation did not cause any significant changes in the enzyme activities of the cyclic AMP system, except of slightly decreased adenylate cyclase activity. The possible relationship of the plasma level of antidiuretic hormone immediately after irradiation and the enzyme activities of cyclic AMP system is discussed.
在单次全身照射1600伦琴后，立即对神经垂体和腺垂体中环磷酸腺苷（cAMP）系统的酶活性进行了研究，以试图找出这种干预是否会导致cAMP调节系统反应性的变化。在受照射的大鼠中，神经垂体显示腺苷酸环化酶活性降低，磷酸二酯酶活性适度增加，蛋白激酶活性略有下降，包括受cAMP刺激的值。在腺垂体中，除腺苷酸环化酶活性略有下降外，照射未引起cAMP系统酶活性的任何显著变化。讨论了照射后立即出现的抗利尿激素血浆水平与cAMP系统酶活性之间的可能关系。
