[器官发生期受照射新生大鼠肝脏中3',5'-单磷酸腺苷的代谢]

[Hepatic adenosine-3',5'-monophosphate metabolism in newborn rats irradiated during the period of organogenesis].

作者信息

Slozhenikina L V, Mikhailets L P, Fialkovskaia L A, Kuzin A M

出版信息

Biull Eksp Biol Med. 1978;86(7):91-3.

Abstract

The adenylate cylcase (AC) and phosphodiesterase (PDE) activities, as well as the 3'5'-AMP (cAMP) fund were studied in the liver of newborn rats, intact, and after irradiation on the 9th day of the embryonic development. A decrease of AC and PDE activities was noted with a dose of 50 r. The stationary level of cAMP in the tissue remained unchanged. The adrenaline-stimulated AC activity only tended to decrease in case of irradiation. As suggested, during critical periods of development, in the presence of the hormone inductor in the liver of irradiated rats, conditions can be created for an increase of the cAMP pool.

摘要

对新生大鼠肝脏、完整胚胎发育第9天的大鼠肝脏以及胚胎发育第9天照射后的大鼠肝脏中的腺苷酸环化酶（AC）和磷酸二酯酶（PDE）活性以及3',5'-环磷酸腺苷（cAMP）水平进行了研究。当辐射剂量为50伦琴时，观察到AC和PDE活性降低。组织中cAMP的稳定水平保持不变。在照射情况下，肾上腺素刺激的AC活性仅呈下降趋势。有人认为，在发育的关键时期，受照射大鼠肝脏中存在激素诱导剂时，可能会为增加cAMP池创造条件。

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Biull Eksp Biol Med. 1978;86(7):91-3.

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