González Rodríguez M D, Sosa Henríquez M, Limiñana Cañal J M, Bentacor León P
Universidad de Las Palmas, Departamento de Patología General y Unidad Metabólica Osea, Hospital Insular.
An Med Interna. 1990 Oct;7(10):500-4.
The aim of the study was to ascertain the importance of calcitonin in the etiopathogenesis of osteoporosis in rats as an animal model. We used 20 female rats on which a thyroidectomy was performed, producing a calcitonin deficit. An autologous transplant of parathyroid gland and replacement therapy of thyroid hormone was carried out. The control group consisted of 20 rats. The levels of parathormone (PTH), calcitonin (CT), osteocalcin (GLA), seric calcium, and density, weight, quantity and mineral bone content of the head of the femur were measured. We found low levels of CT and normal amount of PTH, which contradicted the expected, there was an increment of the mineral bone content, without significant density, quantity and weight changes. We comment on these results.
本研究的目的是确定作为动物模型的大鼠骨质疏松症发病机制中降钙素的重要性。我们使用了20只雌性大鼠，对其进行甲状腺切除术以造成降钙素缺乏。进行了甲状旁腺自体移植和甲状腺激素替代治疗。对照组由20只大鼠组成。测量了甲状旁腺激素（PTH）、降钙素（CT）、骨钙素（GLA）、血清钙以及股骨头部的密度、重量、数量和矿物质骨含量。我们发现CT水平较低而PTH量正常，这与预期不符，矿物质骨含量增加，而密度、数量和重量无明显变化。我们对这些结果进行了评论。
