Department of Toxicology, Faculty of Pharmacy, Medical University, Muszynskiego 1, 90-151 Lodz, Poland.
Ecotoxicol Environ Saf. 2011 Mar;74(3):504-12. doi: 10.1016/j.ecoenv.2010.08.025. Epub 2010 Oct 30.
The aim of the study was to assess the maternal toxicity of polychlorinated naphthalenes (PCNs) and embryotoxic, fetotoxic, and teratogenic effects after administration of the PCN mixture to pregnant rats in four (0.3-9.0 mg/kg bw) daily doses during organogenesis (days 6-15 of gestation). For dams, a dose of 0.3 mg/kg bw, administered during organogenesis, has been established as NOAEL of PCNs, and a dose of 1 mg/kg bw, administered in the same period, as LOAEL. The dose-related fetotoxic (reduced body weight and length of the fetus, extension of renal pelvis and lateral brain ventricles, signs of delayed ossification and retardation in development of internal organs), and teratogenic effects (cleft palate and hydronephrosis) were recorded at all dose levels, also at the dose non-toxic to mothers. PCNs have been concluded to be potent fetotoxic and teratogenic agents producing similar effects to those of other toxic dioxin-like compounds.
本研究旨在评估多氯萘（PCNs）的母体毒性，以及在器官发生期间（妊娠第 6 至 15 天），以每天 4 次（0.3-9.0mg/kg bw）的剂量向怀孕大鼠给予 PCN 混合物后产生的胚胎毒性、胎儿毒性和致畸作用。对于母体，在器官发生期间给予 0.3mg/kg bw 的剂量已被确定为 PCNs 的无明显作用水平（NOAEL），而在同一时期给予 1mg/kg bw 的剂量则为明显作用水平（LOAEL）。在所有剂量水平，包括对母体无毒的剂量，都记录到剂量相关的胎儿毒性（体重和胎儿长度降低、肾盂和侧脑室扩张、骨化延迟和内部器官发育迟缓的迹象）和致畸作用（腭裂和肾盂积水）。PCNs 被认为是具有强大的胚胎毒性和致畸作用的物质，产生与其他有毒类二恶英化合物相似的作用。
