Department of Neonatology, The Royal Children's Hospital, Melbourne, Victoria 3052, Australia.
Early Hum Dev. 2011 Jan;87(1):37-42. doi: 10.1016/j.earlhumdev.2010.09.373. Epub 2010 Oct 30.
Various methods of pain assessment in infants have been trialled in the search for objective, specific, physiologic measures of responses to pain. Skin conductance (SC) measured in the palm of the hand or on the plantar aspect of the foot may be one such measure. SC in these sites reflects the emotional sweating due to sympathetic nerve activity. The skin conductance response (SCR), which results from filling and reabsorption of sweat in the sweat glands, has previously been suggested to be the most sensitive SC parameter of sympathetic nerve activity in response to painful stimulation.
To study SCRs within and between medically stable hospitalised infants while at rest.
SCRs were measured in infants during at least six periods of monitoring in a maximum 48-h period. Behavioural state was recorded throughout the data collection periods.
SC recordings (n=91) from 15 infants during sleep showed that frequency of SCRs varied between 0 and 0.04 SCRs per second (SCRs/s), median 0.002 SCRs/s. 73% of the total variation was within-infant variation, with the remaining 27% of variation due to variation between the mean SCR values of different infants.
This pilot study contributes to establishing baseline phasic SC activity in hospitalised infants at rest by measuring SCRs. These data can be used as a reference for future studies to determine the validity and reliability of SC measurement in infants exposed to painful or stressful interventions within a neonatal unit.
为了寻找对疼痛反应的客观、特异、生理学测量指标，研究人员尝试了各种婴儿疼痛评估方法。手掌或足底的皮肤电传导（SC）可能是这样的一种测量指标。这些部位的 SC 反映了交感神经活动引起的情绪性出汗。皮肤电导反应（SCR）是由于汗腺中的汗液充盈和再吸收而产生的，先前被认为是对疼痛刺激的交感神经活动最敏感的 SC 参数。
研究在医学上稳定的住院婴儿休息时的 SCRs 。
在 48 小时内，至少对 15 名婴儿进行 6 次监测，在此期间测量 SCRs。在整个数据采集期间记录行为状态。
睡眠期间 15 名婴儿的 SC 记录（n=91）显示，SCRs 的频率在 0 到 0.04 SCRs/s 之间变化，中位数为 0.002 SCRs/s。总变异的 73%是个体内变异，其余 27%的变异是由于不同婴儿的平均 SCR 值之间的变异。
这项初步研究通过测量 SCR，为测量在医院休息的婴儿的阵发性 SC 活动提供了基线。这些数据可作为未来研究的参考，以确定在新生儿病房中接受疼痛或应激干预的婴儿的 SC 测量的有效性和可靠性。
