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本文引用的文献

1
Genetic regulation of theAchaete-scute complex ofDrosophila melanogaster.黑腹果蝇achaete - scute复合体的遗传调控
Wilehm Roux Arch Dev Biol. 1984 Jul;193(4):242-245. doi: 10.1007/BF01260345.
2
BCL6 canalizes Notch-dependent transcription, excluding Mastermind-like1 from selected target genes during left-right patterning.BCL6 对 Notch 依赖性转录进行调控，在左右模式形成过程中，将 Mastermind-like1 排除在某些靶基因之外。
Dev Cell. 2010 Mar 16;18(3):450-62. doi: 10.1016/j.devcel.2009.12.023.
3
Promoter-specific co-activation by Drosophila mastermind.果蝇主调控因子的启动子特异性共激活作用
Biochem Biophys Res Commun. 2008 Dec 12;377(2):658-661. doi: 10.1016/j.bbrc.2008.10.035. Epub 2008 Oct 16.
4
Notch activation stimulates transient and selective binding of Su(H)/CSL to target enhancers.Notch激活刺激Su(H)/CSL与靶增强子的瞬时和选择性结合。
Genes Dev. 2007 Jun 1;21(11):1322-7. doi: 10.1101/gad.424607.
5
Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription.高阶Notch复合体的协同组装作为一种开关来诱导转录。
Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2103-8. doi: 10.1073/pnas.0611092104. Epub 2007 Feb 6.
6
Notch signalling: a simple pathway becomes complex.Notch信号通路：一条简单的通路变得复杂起来。
Nat Rev Mol Cell Biol. 2006 Sep;7(9):678-89. doi: 10.1038/nrm2009.
7
Bearded family members inhibit Neuralized-mediated endocytosis and signaling activity of Delta in Drosophila.有须的家庭成员抑制果蝇中Neuralized介导的Delta内吞作用和信号活性。
Dev Cell. 2006 Feb;10(2):245-55. doi: 10.1016/j.devcel.2005.12.017.
8
Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability.脊椎动物Notch蛋白的靶点选择性。离散结构域与CSL结合位点结构之间的协作决定激活概率。
J Biol Chem. 2006 Feb 24;281(8):5106-19. doi: 10.1074/jbc.M506108200. Epub 2005 Dec 19.
9
Hairless-mediated repression of notch target genes requires the combined activity of Groucho and CtBP corepressors.无毛蛋白介导的Notch靶基因抑制需要Gro和CtBP共抑制因子的联合活性。
Mol Cell Biol. 2005 Dec;25(23):10433-41. doi: 10.1128/MCB.25.23.10433-10441.2005.
10
The Notch targets Esr1 and Esr10 are differentially regulated in Xenopus neural precursors.在非洲爪蟾神经前体细胞中，Notch的靶基因Esr1和Esr10受到不同的调控。
Development. 2005 Aug;132(16):3619-30. doi: 10.1242/dev.01937.

在神经前体细胞簇中的 Notch 信号传导过程中，通过不同的 Suppressor of Hairless DNA 结合位点结构对转录进行差异调控。

Differential regulation of transcription through distinct Suppressor of Hairless DNA binding site architectures during Notch signaling in proneural clusters.

机构信息

Burke Medical Research Institute, 785 Mamaroneck Ave., White Plains, NY 10605, USA.

出版信息

Mol Cell Biol. 2011 Jan;31(1):22-9. doi: 10.1128/MCB.00003-10. Epub 2010 Nov 1.

DOI:10.1128/MCB.00003-10
PMID:21041480
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3019852/
Abstract

In Drosophila melanogaster, achaete (ac) and m8 are model basic helix-loop-helix activator (bHLH A) and repressor genes, respectively, that have the opposite cell expression pattern in proneural clusters during Notch signaling. Previous studies have shown that activation of m8 transcription in specific cells within proneural clusters by Notch signaling is programmed by a "combinatorial" and "architectural" DNA transcription code containing binding sites for the Su(H) and proneural bHLH A proteins. Here we show the novel result that the ac promoter contains a similar combinatorial code of Su(H) and bHLH A binding sites but contains a different Su(H) site architectural code that does not mediate activation during Notch signaling, thus programming a cell expression pattern opposite that of m8 in proneural clusters.

摘要

在黑腹果蝇中，achaete (ac) 和 m8 分别是模型碱性螺旋-环-螺旋激活子（bHLH A）和阻遏子基因，在 Notch 信号传导过程中，它们在神经前簇中的细胞表达模式相反。先前的研究表明， Notch 信号通过特定的细胞内 m8 转录激活，是由包含 Su(H) 和神经前 bHLH A 蛋白结合位点的“组合”和“结构”DNA 转录代码编程的。在这里，我们展示了一个新的结果，即 ac 启动子包含一个类似的 Su(H)和 bHLH A 结合位点的组合代码，但包含一个不同的 Su(H) 位点结构代码，该代码在 Notch 信号传导过程中不介导激活，从而编程了神经前簇中与 m8 相反的细胞表达模式。