Moscoso Del Prado J, Garcia-Bellido A
Centro de Biologia Molecular, Consejo Superior de Investigaciones Cientificas, Cantoblanco, 34, Madrid, Spain.
Wilehm Roux Arch Dev Biol. 1984 Jul;193(4):242-245. doi: 10.1007/BF01260345.
Mutants in two loci,hairy (h ) andextramacrochaetae (emc ), produce phenotypes corresponding to an excess of function of theachaete-scute complex (AS-C), that is, they cause the appearance of extra chaetae. These mutants, although recessive in normal flies, become dominant in the presence of extra doses of AS-C. Here we study the interactions between these three genes, in an attempt to elucidate their relationships. The results show that the insufficiency produced byh oremc mutants can be titrated by altering the number of copies of AS-C. Moreover, excess of function of AS-C produced by derepression mutants within the complex (Hairy-wing) can also be titrated by altering the number of wild type copies of oremc . These specific interactions indicate that bothh andemc code for "repressors" of AS-C that interact with theachaete andscute region of the complex respectively.
两个基因座的突变体，多毛（h）和超大刚毛（emc），产生的表型对应于achaete - scute复合体（AS - C）功能的过量，也就是说，它们会导致额外刚毛的出现。这些突变体在正常果蝇中虽然是隐性的，但在存在额外剂量的AS - C时会变为显性。在这里，我们研究这三个基因之间的相互作用，试图阐明它们的关系。结果表明，h或emc突变体产生的功能不足可以通过改变AS - C的拷贝数来调节。此外，复合体（毛翅）内去抑制突变体产生的AS - C功能过量也可以通过改变h或emc的野生型拷贝数来调节。这些特定的相互作用表明，h和emc都编码AS - C的“抑制因子”，它们分别与复合体的achaete和scute区域相互作用。
