Ruiz-Carrascoso Guillermo, Casas Inmaculada, Pozo Francisco, González-Vincent Marta, Pérez-Breña Pilar
Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain.
Antivir Ther. 2010;15(7):1059-63. doi: 10.3851/IMP1657.
In this study, we report a case of multidrug-resistant influenza A(H3N2) virus isolated from an immunosuppressed patient with prolonged viral shedding. We also describe the genetic characterization of the haemagglutinin, neuraminidase and M2 influenza genes. The virus contained the substitutions E119V in neuraminidase and V27A in M2, which produce resistance to oseltamivir and adamantanes, respectively. This is the first report of this dual mutation pattern in multidrug-resistant influenza A(H3N2) virus.
在本研究中，我们报告了一例从一名病毒长期脱落的免疫抑制患者中分离出的耐多药甲型H3N2流感病毒病例。我们还描述了血凝素、神经氨酸酶和M2流感基因的基因特征。该病毒在神经氨酸酶中含有E119V替换，在M2中含有V27A替换，分别对奥司他韦和金刚烷产生耐药性。这是耐多药甲型H3N2流感病毒中这种双重突变模式的首次报告。
