Department of Cardiology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey.
J Atheroscler Thromb. 2011;18(3):177-81. doi: 10.5551/jat.6189. Epub 2010 Oct 28.
Gamma-glutamyltransferase (GGT), regarded as a marker of excessive alcohol consumption or liver disturbances, is an enzyme catalyzing the first step in the extracellular degradation of the antioxidant glutathione (GSH) and may take part in atherogenesis. The marked relationship between GGT and the atherosclerotic process has shifted attention to the issue of whether its serum levels can aid in the detection of individuals at high risk for incident cardiovascular events. It is likely that the process entails the oxidation of low-density lipoprotein through GSH/GGT-dependent iron reduction within the plaque. In this context, oxidative stress is a probable mediator. Recent insights into the pathophysiological background of GGT in the precipitation and progression of atherosclerosis appear to be supported by relevant epidemiological observations as a cardiovascular risk predictor. Further understanding is, nevertheless, warranted to ameliorate the prognostic stratification of patients through GGT.
谷氨酰转移酶（GGT）被认为是过量饮酒或肝脏紊乱的标志物，是催化抗氧化谷胱甘肽（GSH）细胞外降解第一步的酶，可能参与动脉粥样硬化的形成。GGT 与动脉粥样硬化过程之间的显著关系引起了人们的关注，即其血清水平是否有助于检测发生心血管事件的高危个体。该过程很可能涉及通过斑块内 GSH/GGT 依赖性铁还原氧化低密度脂蛋白。在这种情况下，氧化应激可能是一个中介。最近的研究表明，GGT 在动脉粥样硬化的沉淀和进展中的病理生理背景似乎得到了相关流行病学观察的支持，作为心血管风险预测因子。然而，进一步的理解是必要的，以通过 GGT 改善患者的预后分层。
