Departamento de Química Orgánica, Facultad de Química, Universidad de Sevilla, Apartado 553, E-41071 Sevilla, Spain.
Chem Soc Rev. 2011 Mar;40(3):1586-608. doi: 10.1039/c0cs00019a. Epub 2010 Nov 1.
Cyclodextrin (CD) history has been largely dominated by their unique ability to form inclusion complexes with guests fitting in their hydrophobic cavity. Chemical funcionalization was soon recognized as a powerful mean for improving CD applications in a wide range of fields, including drug delivery, sensing or enzyme mimicking. However, 100 years after their discovery, CDs are still perceived as novel nanoobjects of undeveloped potential. This critical review provides an overview of different strategies to promote interactions between CD conjugates and genetic material by fully exploiting the inside-outside/upper-lower face anisotropy of the CD nanometric platform. Covalent modification, self-assembling and supramolecular ligation can be put forward with the ultimate goal to build artificial viruses for programmed and efficient gene therapy (222 references).
环糊精（CD）的历史在很大程度上主要由其与适合其疏水性空腔的客体形成包合物的独特能力所主导。化学功能化很快被认为是改善 CD 在包括药物输送、传感或酶模拟在内的广泛领域应用的有力手段。然而，在发现 100 年后，CD 仍然被认为是潜在尚未开发的新型纳米物体。这篇评论批判性地概述了不同策略，通过充分利用 CD 纳米平台的内外/上下面各向异性，来促进 CD 缀合物与遗传物质之间的相互作用。共价修饰、自组装和超分子连接可以被提出来，最终目标是构建用于编程和高效基因治疗的人工病毒（222 篇参考文献）。
