胚胎因素与妊娠率的相关性：冷冻保存方案中胚胎评分的制定。
Correlation between embryological factors and pregnancy rate: development of an embryo score in a cryopreservation programme.
机构信息
Servei de Medicina de la Reproducció, Departament d'Obstetrícia, Ginecologia i Reproducció, Institut Universitari Dexeus, Sabino de Arana, 5-19, 08028, Barcelona, Spain.
出版信息
J Assist Reprod Genet. 2011 Feb;28(2):129-36. doi: 10.1007/s10815-010-9498-0. Epub 2010 Nov 2.
Abstract
PURPOSE
To establish which embryo parameters, in frozen thawed embryo transfers, have the highest prognosis value in the establishment of pregnancy. The relative importance of different embryo parameters is used to develop an embryo score.
METHODS
Retrospective analysis of the implantation rate in 356 frozen/thawed single embryo transfers. A logistic regression model is used to establish an embryo score.
RESULTS
A direct correlation is established between the implantation rate and fresh embryo development (number of blastomeres and their symmetry), survival rate after thawing and mitosis resumption after overnight culture.
CONCLUSIONS
An embryo score is developed to determine the implantation potential of frozen/thawed embryos.
摘要
目的
确定在冻融胚胎移植中，哪些胚胎参数对妊娠的建立具有最高的预测价值。利用不同胚胎参数的相对重要性来制定胚胎评分。
方法
对 356 例冻融单胚胎移植的种植率进行回顾性分析。采用逻辑回归模型建立胚胎评分。
结果
胚胎种植率与新鲜胚胎发育（卵裂球数量和对称性）、解冻后存活率以及过夜培养后有丝分裂恢复之间呈直接相关。
结论
制定胚胎评分以确定冻融胚胎的种植潜能。
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