Lundin Kersti, Bergh Christina
Reproductive Medicine, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden.
Reprod Biomed Online. 2007 Jul;15(1):76-82. doi: 10.1016/s1472-6483(10)60695-5.
Randomized control trials have shown that single embryo transfer (SET) results in lower live birth rates than double embryo transfer (DET), while observational, retrospective studies find no decrease in overall live birth rate when using a SET policy. The cumulative (fresh transfer followed by frozen - thawed transfers of embryos from the same stimulated cycle) live birth rate after the first and the second stimulated cycle of SET and DET respectively has been analysed. All couples who received their first fresh embryo transfer at Sahlgrenska University Hospital during 2003 and 2004 were included (n = 689). The live birth rates after DET versus SET in the first and second fresh cycles were 29.7 (47/158) versus 23.9% (127/531) and 30.8 (41/133) versus 22.0% (45/205). The cumulative live birth rate per patient after the addition of frozen-thawed embryo transfers were similar: 33.5 (53/158) and 34.8% (185/531) for DET and SET respectively after the first cycle and 32.3 (43/133) versus 32.2% (66/205) after the second cycle. A logistic regression analysis showed no significant correlation for SET or DET with cumulative live birth. Thus, cumulative live birth rates are similar after SET and DET in a routine IVF programme with a majority of SET transfers, although a higher number of frozen-thawed cycles were needed in the SET group.
随机对照试验表明，单胚胎移植（SET）的活产率低于双胚胎移植（DET），而观察性、回顾性研究发现，采用SET策略时总体活产率并未降低。分别分析了SET和DET在第一个和第二个刺激周期后的累积（新鲜移植后接着移植来自同一刺激周期的冻融胚胎）活产率。纳入了2003年至2004年期间在萨尔格伦斯卡大学医院接受首次新鲜胚胎移植的所有夫妇（n = 689）。在第一个和第二个新鲜周期中，DET与SET后的活产率分别为29.7%（47/158）对23.9%（127/531）以及30.8%（41/133）对22.0%（45/205）。添加冻融胚胎移植后每位患者的累积活产率相似：第一个周期后，DET和SET分别为33.5%（53/158）和34.8%（185/531）；第二个周期后，分别为32.3%（43/133）对32.2%（66/205）。逻辑回归分析显示，SET或DET与累积活产之间无显著相关性。因此，在大多数为SET移植的常规体外受精程序中，SET和DET后的累积活产率相似，尽管SET组需要更多的冻融周期。
