Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Unit 1202, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
Curr Oncol Rep. 2011 Feb;13(1):77-85. doi: 10.1007/s11912-010-0134-z.
The introduction of concurrent chemotherapy and radiotherapy for the definitive treatment of cervical cancer constituted a major advance in the management of cervical cancer, resulting in a significant improvement in local control, progression-free survival, and overall survival. Since the publication of the results of seminal trials demonstrating the benefits of platinum-based chemotherapy, investigations of new cytotoxic and targeting agents have continued. The success of these studies has been limited in part because the side effects of standard platinum-based chemoradiation regimens already approach the limits of tolerability. Future progress will depend on identifying new agents without overlapping toxic effects, improving supportive care, and minimizing the toxic effects of radiation.
同期放化疗作为宫颈癌的根治性治疗手段的引入，是宫颈癌治疗的重大进展，显著改善了局部控制、无进展生存期和总生存期。自具有里程碑意义的研究结果发表以来，表明了铂类为基础的化疗的益处，对新的细胞毒性药物和靶向药物的研究一直在继续。这些研究的成功在一定程度上受到限制，因为标准铂类放化疗方案的副作用已经接近可耐受的极限。未来的进展将取决于能否发现无重叠毒性作用的新药物，改善支持性护理，以及最大限度地减少放疗的毒性作用。
