Luchsinger Vivian, Luzoro Amaranta, Martínez María José
Programa de Virología, ICBM, Facultad de Medicina, Universidad de Chile.
Rev Med Chil. 2010 Jul;138(7):809-14. doi: 10.4067/s0034-98872010000700003.
Cytomegalovirus (CMV), herpes simplex type I (HSV-1) and Epstein Barr virus (EBV) are latent persistent infections. Their reactivation may cause illnesses and death in human immunodeficiency virus-infected (HIV) people. World wide seroprevalence of these viruses is over 50%. In Chile, information is not available.
To determine the seroprevalence of CMV HSV-1 and EBV in Chilean HIV-infected adults.
A total of 400 HIV-infected adults aged 17 to 67 years (340 males) were studied during 2005 and 2006 CMV HSV-1 and EBV serum antibodies were measured by enzyme-linked immunoabsorbent assay.
The mean lapse from the diagnosis of HIV and serum testing was 67 months and 69.5% patients received antiretroviral therapy. Sixty seven percent of the sample were men who had sex with men (MSM). The seroprevalence for CM, HSV-1 and EBV were 98.5, 92.2 and 99.7%, respectively. No patient had negative antibodies for all three viruses. Male patients that were negative for HSV-1 had a lower frequency of MSM than the rest of males (26% vs. 62%, p < 0.01).
There is a high prevalence of positive antibodies against CMV HSV-1 and EBV in Chilean adults infected with HIV Specific diagnostic tests and antiviral therapy should be available for these patients.
巨细胞病毒（CMV）、单纯疱疹病毒I型（HSV-1）和爱泼斯坦-巴尔病毒（EBV）是潜伏性持续性感染。它们的重新激活可能导致人类免疫缺陷病毒（HIV）感染者患病和死亡。这些病毒在全球的血清阳性率超过50%。在智利，尚无相关信息。
确定智利HIV感染成人中CMV、HSV-1和EBV的血清阳性率。
2005年至2006年期间，对400名年龄在17至67岁的HIV感染成人（340名男性）进行了研究。通过酶联免疫吸附测定法检测CMV、HSV-1和EBV血清抗体。
从HIV诊断到血清检测的平均间隔时间为67个月，69.5%的患者接受了抗逆转录病毒治疗。67%的样本为男男性行为者（MSM）。CMV、HSV-1和EBV的血清阳性率分别为98.5%、92.2%和99.7%。没有患者三种病毒的抗体均为阴性。HSV-1抗体阴性的男性患者中MSM的比例低于其他男性（26%对62%，p<0.01）。
智利HIV感染成人中抗CMV、HSV-1和EBV的阳性抗体患病率很高。应为这些患者提供特定的诊断检测和抗病毒治疗。
