Infectious Disease Epidemiology Group, Weill Cornell Medicine-Qatar, Cornell University, Qatar Foundation-Education City, Doha, Qatar.
Department of Health Sciences, Qatar University, Doha, Qatar.
PLoS One. 2019 Apr 22;14(4):e0215487. doi: 10.1371/journal.pone.0215487. eCollection 2019.
To investigate the epidemiology of herpes simplex virus type 1 (HSV-1) in Latin America and the Caribbean.
Systematic review and meta-analytics guided by the Cochrane Collaboration Handbook and reported following the PRISMA guidelines.
Thirty-three relevant reports were identified including 35 overall (and 95 stratified) seroprevalence measures, and five and nine proportions of virus isolation in genital ulcer disease (GUD) and in genital herpes, respectively. Pooled mean seroprevalence was 57.2% (95% CI: 49.7-64.6%) among children and 88.4% (95% CI: 85.2-91.2%) among adults. Pooled mean seroprevalence was lowest at 49.7% (95% CI: 42.8-56.6%) in those aged ≤10, followed by 77.8% (95% CI: 67.9-84.8%) in those aged 10-20, 82.8% (95% CI: 73.1-90.8%) in those aged 20-30, 92.5% (95% CI: 89.4-95.1%) in those aged 30-40, and 94.2% (95% CI: 92.7-95.5%) in those aged ≥40. Age was the strongest source of heterogeneity in seroprevalence, explaining 54% of variation. Evidence was found for seroprevalence decline over time. Pooled mean proportion of HSV-1 isolation was 0.9% (95% CI: 0.0-3.6%) in GUD and 10.9% (95% CI: 4.4-19.4%) in genital herpes.
HSV-1 is a widely prevalent infection in this region, but its epidemiology may be slowly transitioning, with still limited contribution for HSV-1 in genital herpes.
调查拉丁美洲和加勒比地区单纯疱疹病毒 1 型（HSV-1）的流行病学。
系统评价和荟萃分析，遵循 Cochrane 协作组手册，并按照 PRISMA 指南进行报告。
确定了 33 份相关报告，包括 35 项总体（和 95 项分层）血清流行率测量，以及分别在生殖器溃疡病（GUD）和生殖器疱疹中病毒分离的 5 项和 9 项比例。儿童的平均血清流行率为 57.2%（95%可信区间：49.7-64.6%），成人的平均血清流行率为 88.4%（95%可信区间：85.2-91.2%）。在年龄≤10 岁的人群中，平均血清流行率最低为 49.7%（95%可信区间：42.8-56.6%），其次是年龄为 10-20 岁的人群，为 77.8%（95%可信区间：67.9-84.8%），年龄为 20-30 岁的人群为 82.8%（95%可信区间：73.1-90.8%），年龄为 30-40 岁的人群为 92.5%（95%可信区间：89.4-95.1%），年龄≥40 岁的人群为 94.2%（95%可信区间：92.7-95.5%）。年龄是血清流行率差异的最强来源，解释了 54%的变异。有证据表明，随着时间的推移，血清流行率呈下降趋势。在 GUD 中，HSV-1 分离的平均比例为 0.9%（95%可信区间：0.0-3.6%），在生殖器疱疹中为 10.9%（95%可信区间：4.4-19.4%）。
HSV-1 在该地区是一种广泛流行的感染，但它的流行病学可能正在缓慢转变，生殖器疱疹中 HSV-1 的贡献仍然有限。
