Institute of Pathobiochemistry, Medical School of Erfurt.
Platelets. 1994;5(5):240-4. doi: 10.3109/09537109409006428.
The sulphhydryl group containing drug N-(2-mercaptopropionyl)-glycine (MPG) was tested as a cytoprotective substance for storage of human platelets for transfusion. Autologous platelets stored for 48 h at 21 ± 1°C in the absence (control-platelets) or in the presence (MPG-platelets) of MPG, respectively, were labelled with Indium-III oxine and retransfused into the healthy donors. Significantly higher survival and a higher spleen/liver-ratio were obtained using stored MPG-platelets compared to stored control-platelets. Additionally, a very strong correlation was found between the percentage of discocytes counted after incubation of stored platelets in fresh plasma in vitro and the survival of stored platelets after retransfusion in vivo.
含巯基的药物 N-(2-巯基丙酰基)-甘氨酸（MPG）被测试为用于人类血小板保存以用于输血的细胞保护物质。分别在 21±1°C 下储存 48 小时的自体血小板在不存在（对照血小板）或存在（MPG 血小板）MPG 的情况下，用铟-III 氧代乙酸盐标记，然后重新输注到健康供体中。与储存的对照血小板相比，使用储存的 MPG 血小板可获得更高的存活率和更高的脾脏/肝脏比值。此外，还发现体外新鲜血浆孵育储存血小板后计算的盘状细胞百分比与体内重新输注储存血小板后的存活率之间存在很强的相关性。
